Research and Development Costs and Drug Pricing: Link Tenuous at Best by F. Perry Wilson

A study appearing in JAMA Internal Medicine links the cost of developing a new drug to the ultimate revenue a company receives. The results suggest that curbing R&D costs may not have much effect on drug pricing at all. For the video version, click here.

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PSA Screening for Prostate Cancer Gets a Shot in the Arm by F. Perry Wilson

PSA screening for prostate cancer has been on the decline largely due to the negative results of the PLCO trial. But this analysis appearing in the Annals of Internal Medicine suggest that it is not PSA testing that is flawed, but the trial design. For the video version, click here.

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Trump Isn't Crazy, We Are: Doc-to-Doc with Allen Frances, MD by F. Perry Wilson

Dr. Allen Frances is a Professor Emeritus of Psychiatry at Duke University and the creator of the diagnostic criteria for narcissistic personality disorder. That condition has been in the news frequently, as many have suggested that President Trump may be so afflicted. In his new book, Twilight of American Sanity, Dr. Frances suggests that it is not Trump who is crazy. It is us. 

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Estrogen Pills, Patches, and Sex After Menopause by F. Perry Wilson

A randomized trial appearing in JAMA Internal Medicine reveals modest, but significant effects of transdermal estrogen on sexual function in post-menopausal women. But there are some caveats. For the video version, click here.

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Work Hours in Dual-Physician Couples: The Effect of Children by F. Perry Wilson

A research letter appearing in JAMA Internal Medicine documents a striking decrease in work hours among women physicians once they have children - a finding that does not extend to their male physician spouses. For the video version, click here.

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Ending Medical Reversal: Doc-to-Doc with Vinay Prasad, MD by F. Perry Wilson

"Medical Reversal" occurs when new data demonstrates that a commonly-accepted practice is not beneficial or even harmful to patients. Dr. Vinay Prasad is a world-expert in this phenomenon. I spoke to him about the trends in medical reversals, their underpinnings, and how they can be ended in the future. His book is entitled "Ending Medical Reversal: Improving Outcomes, Saving Lives".

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What the Market Will Bear: Doc-to-Doc on Skyrocketing Drug Prices with Dr. Umesh Khot by F. Perry Wilson

Dr. Umesh Khot is the Vice-Chairman of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine at the Cleveland Clinic and the author of a research letter in the New England Journal of Medicine examining the effects of the astronomical price increases of isoproteronol and nitroprusside. In this doc-to-doc interview, Dr. Khot discusses the reasons the prices increased, the effects that had on utilization of the drugs, and the implications this has more broadly in our healthcare system.

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